Biomedical Sciences Won the Robert Gates-muller Family Outstanding Student Award
| Robert Lefkowitz | |
|---|---|
 Robert Lefkowitz in Stockholm 2012 | |
| Built-in | Robert Joseph Lefkowitz (1943-04-fifteen) April 15, 1943 The Bronx, New York City, New York, USA |
| Nationality | American |
| Alma mater | Columbia Academy |
| Known for | K protein coupled receptors beta-arrestins |
| Spouse(s) | Arna Brandel (divorced) Lynn Tilley (m. 1991) |
| Awards | National Medal of Scientific discipline (2007) BBVA Foundation Frontiers of Knowledge Award (2009) Nobel Prize in Chemistry (2012) |
| Scientific career | |
| Fields | Receptor Biology Biochemistry |
| Institutions | Duke University Howard Hughes Medical Found |
| Notable students | Brian Kobilka,[ane] Jeffrey Benovic, Michel Bouvier, Marc G. Caron, Richard A. Cerione, Henrik Dohlman, Walter J. Koch, Lee Limbird,[2] Martin J. Lohse, Gang Pei, Lewis "Rusty" Williams, R. Sanders Williams |
Robert Joseph Lefkowitz (born April 15, 1943) is an American physician (internist and cardiologist) and biochemist. He is all-time known for his groundbreaking discoveries that reveal the inner workings of an of import family unit G protein-coupled receptors, for which he was awarded the 2012 Nobel Prize for Chemistry with Brian Kobilka. He is currently an Investigator with the Howard Hughes Medical Found likewise as a James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at Duke University.
Early life [edit]
Lefkowitz was born on Apr 15, 1943, in The Bronx, New York to Jewish parents Max and Rose Lefkowitz. Their families had emigrated to the United States from Poland in the late 19th century.[three] [four]
After graduating from the Bronx Loftier School of Science in 1959,[v] he attended Columbia College from which he received a Available of Arts in chemistry 1962.[6]
He graduated from Columbia University College of Physicians and Surgeons in 1966 with an Chiliad.D. Degree. Subsequently serving an internship and one year of general medical residency at the College of Physicians and Surgeons, he served as Clinical and Inquiry Acquaintance at the National Institutes of Wellness from 1968 to 1970.
Career [edit]
Upon completing his medical residency and research and clinical training in 1973, he was appointed Associate Professor of Medicine and Banana Professor of Biochemistry at the Duke University Medical Eye. In 1977, he was promoted to Professor of Medicine and in 1982 to James B. Knuckles Professor of Medicine at Duke University.[vii] He is also a Professor of Biochemistry and a Professor of Chemistry. He has been an Investigator of the Howard Hughes Medical Institute since 1976 and was an Established Investigator of the American Heart Association from 1973–1976.[vii]
Lefkowitz studies receptor biology and signal transduction and is most well known for his detailed characterizations of the sequence, structure and function of the β-adrenergic and related receptors and for the discovery and label of the two families of proteins which regulate them, the G protein-coupled receptor (GPCR) kinases and β-arrestins.[8]
Lefkowitz made a remarkable contribution in the mid-1980s when he and his colleagues cloned the gene first for the β-adrenergic receptor, and and so rapidly thereafter, for a full of eight adrenergic receptors (receptors for adrenaline and noradrenaline). This led to the seminal discovery that all GPCRs (which include the β-adrenergic receptor) have a very similar molecular structure. The structure is defined by an amino acid sequence which weaves its way back and forth across the plasma membrane seven times. Today nosotros know that about 1,000 receptors in the human body belong to this same family unit. The importance of this is that all of these receptors employ the same basic mechanisms so that pharmaceutical researchers at present understand how to effectively target the largest receptor family in the homo trunk. Today, as many as xxx to 50 percent of all prescription drugs are designed to "fit" like keys into the similarly structured locks of Lefkowitz' receptors—everything from anti-histamines to ulcer drugs to beta blockers that help relieve hypertension, angina and coronary disease.[nine] Lefkowitz is among the most highly cited researchers in the fields of biological science, biochemistry, pharmacology, toxicology, and clinical medicine according to Thomson-ISI.[10]
Personal life [edit]
Lefkowitz is married to Lynn (née Tilley). He has five children and six grandchildren. He was previously married to Arna Brandel.[6]
In 2021, Lefkowitz published a memoir entitled A Funny Matter Happened on the Way to Stockholm: The Adrenaline-Fueled Adventures of an Accidental Scientist.[eleven] This book was co-authored past Randy Hall, who was a post-doctoral beau in the Lefkowitz lab in the 1990'south. The book describes Lefkowitz's early life, training as a physician, and tenure in the Us Public Wellness Service (the "Yellow Berets" of the NIH), which began as a means of fulfilling his draft obligation during the Vietnam State of war but ultimately ignited a lifelong passion for enquiry. The 2d half of the volume describes Lefkowitz's enquiry career and various adventures both before and after his Nobel Prize win. Upon publication in February 2021, the volume was named as "New & Noteworthy" by The New York Times [12] and "one of the week'due south all-time scientific discipline picks" by Nature.[13]
Awards [edit]
Lefkowitz has received numerous awards including:
- 2014 Aureate Plate Award of the American Academy of Achievement[xiv]
- 2012 Nobel Prize in Chemistry (shared with Brian Kobilka)
- 2009 BBVA Foundation Frontiers of Knowledge Laurels, in the Biomedicine Category.[15]
- 2009 Research Accomplishment Honor, American Centre Clan[16]
- 2007 National Medal of Scientific discipline[17] [18]
- 2007 The Shaw Prize in Life Science and Medicine [nineteen]
- 2007 Albany Medical Center Prize in Medicine and Biomedical Inquiry [20]
- 2003 Fondation Lefoulon – Delalande G Prix for Science – Institut de France[21]
- 2001 Jessie Stevenson Kovalenko Medal of the USA – The National Academy of Sciences [22]
- 1992 Bristol-Myers Squibb Award for Distinguished Achievement In Cardiovascular Research[23]
- 1988 Gairdner Foundation International Award[24]
- 1978 John Jacob Abel Honour in Pharmacology [25]
References [edit]
- ^ "The Nobel Prize in Chemistry 2012". NobelPrize.org.
- ^ Snyder, Pecker. "Nobel in Chemistry reveals VU ties that bind". Vanderbilt University.
- ^ Ralph Snyderman (2011-ten-03). "Introduction of Robert J. Lefkowitz". Jci.org. Retrieved 2012-ten-12 .
- ^ Jay Price (2012-12-30). "Dr. Robert Lefkowitz, Nobel in hand, still shapes immature researchers". News & Observer. Archived from the original on 2013-01-20. Retrieved 2013-01-17 .
- ^ Newman, Andy (October 10, 2012). "Another Nobel for Bronx Science, This One in Chemistry". New York Times.
- ^ a b "Archived copy". Archived from the original on 2013-01-20. Retrieved 2013-01-17 .
{{cite spider web}}: CS1 maint: archived copy as title (link) - ^ a b "HHMI Investigators – Robert J. Lefkowitz, K.D". Howard Hughes Medical Establish. Retrieved 2013-01-14 .
- ^ "Robert J. Lefkowitz, M.D. Biography and Interview". world wide web.achievement.org. American Academy of Achievement.
- ^ "Pioneers of prison cell receptor inquiry share America'southward pinnacle prize in medicine". Albany Medical Center Website.
- ^ "Highly Cited Research – Enquiry Analytics – Thomson Reuters". Hcr3.webofknowledge.com. 2011-12-31. Retrieved 2012-10-12 . [ permanent dead link ]
- ^ "A Funny Affair Happened on the Way to Stockholm". pegasusbooks.com . Retrieved 2021-03-31 .
- ^ "New & Noteworthy, From Food Policy to Communicating With the Dead". The New York Times. 2021-02-02. ISSN 0362-4331. Retrieved 2021-03-31 .
- ^ Robinson, Andrew (2021-03-17). "The accidental Nobel laureate, what we owe to our voices and the philosophy of touch: Books in Brief". Nature. 591 (7850): 364–364. doi:10.1038/d41586-021-00661-four.
- ^ "Golden Plate Awardees of the American University of Achievement". world wide web.achievement.org. American University of Accomplishment.
- ^ "Biomedicine 2009 Robert J. Lefkowitz". BBVA Foundation Frontiers of Knowledge Awards. Retrieved 2013-01-xiv .
- ^ "N Carolina scientist wins American Heart Association award for discovering receptors' role as specific targets for drug therapy". American Center Association. 2009-eleven-15. Retrieved 2013-01-14 .
- ^ "Robert Lefkowitz receiving the National Medal of Scientific discipline". Knuckles University. 2008-09-28. Archived from the original on 2021-12-21. Retrieved 2013-01-14 . – YouTube video of the ceremony
- ^ Duke Medicine News and Communications (2008-09-28). "Duke Medicine Physician-Scientist Receives National Medal of Science". Duke Health.org. Retrieved 2013-01-fourteen .
- ^ "Announcement and Citation". The Shaw Prize. 2007-06-12. Retrieved 2013-01-14 .
- ^ "Albany Medical Center Prize". Albany Medical Higher. Archived from the original on 2012-07-17. Retrieved 2013-01-fourteen .
- ^ "Fondation Lefoulon Delalande – Historique des prix". Fondation Lefoulon – Delalande. Retrieved 2013-01-xiv .
- ^ "Jessie Stevenson Kovalenko Medal". National Academy of Sciences . Retrieved 2013-01-xiv .
- ^ "Bristol Myers Squib Achievements". Bristol-Myers Squibb. Retrieved 2013-01-fourteen .
- ^ "Robert J. Lefkowitz". Gairdner. Retrieved 2013-01-14 .
- ^ "Previous Winners of Society Awards" (PDF). American Society for Pharmacology and Experimental Therapeutics. Retrieved 2013-01-14 .
External links [edit]
- "Lefkowitz Lab". Retrieved 2013-01-14 . – Web site of his lab.
- "HHMI Investigators – Robert J. Lefkowitz, Yard.D". Howard Hughes Medical Plant. Retrieved 2013-01-fourteen . – His biography.
- Robert J. Lefkowitz Papers at Duke Academy Medical Center Archives
- Video of Lefkowitz talking about his work, from the National Science & Applied science Medals Foundation]
- Robert Lefkowitz on Nobelprize.org
- A Funny Thing Happened on the Way to Stockholm
Source: https://en.wikipedia.org/wiki/Robert_Lefkowitz
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